Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GE_agg.GE_agg.cls#LTED_versus_MCF7p.GE_agg.cls#LTED_versus_MCF7p_repos |
| Phenotype | GE_agg.cls#LTED_versus_MCF7p_repos |
| Upregulated in class | MCF7p |
| GeneSet | METFORMIN HYDROCHLORIDE |
| Enrichment Score (ES) | -0.4034177 |
| Normalized Enrichment Score (NES) | -1.2271067 |
| Nominal p-value | 0.15333334 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | 4541 | NA | ND6 Entrez, Source | NADH dehydrogenase, subunit 6 (complex I) | 4023 | 0.183 | -0.1519 | No |
| 2 | 367 | NA | AR Entrez, Source | androgen receptor | 4147 | 0.175 | -0.1275 | No |
| 3 | 25915 | NA | NDUFAF3 Entrez, Source | NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 | 4817 | 0.140 | -0.1340 | No |
| 4 | 4711 | NA | NDUFB5 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa | 5197 | 0.124 | -0.1300 | No |
| 5 | 4535 | NA | ND1 Entrez, Source | NADH dehydrogenase, subunit 1 (complex I) | 5294 | 0.120 | -0.1139 | No |
| 6 | 4705 | NA | NDUFA10 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | 6560 | 0.078 | -0.1582 | No |
| 7 | 4537 | NA | ND3 Entrez, Source | NADH dehydrogenase, subunit 3 (complex I) | 6688 | 0.074 | -0.1514 | No |
| 8 | 4718 | NA | NDUFC2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa | 7118 | 0.061 | -0.1605 | No |
| 9 | 4723 | NA | NDUFV1 Entrez, Source | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa | 7265 | 0.057 | -0.1573 | No |
| 10 | 4695 | NA | NDUFA2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa | 7837 | 0.046 | -0.1755 | No |
| 11 | 4716 | NA | NDUFB10 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa | 8117 | 0.041 | -0.1812 | No |
| 12 | 4729 | NA | NDUFV2 Entrez, Source | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 8288 | 0.038 | -0.1825 | No |
| 13 | 4722 | NA | NDUFS3 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) | 9386 | 0.019 | -0.2291 | No |
| 14 | 4715 | NA | NDUFB9 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa | 9437 | 0.019 | -0.2282 | No |
| 15 | 4697 | NA | NDUFA4 Entrez, Source | NDUFA4, mitochondrial complex associated | 9778 | 0.013 | -0.2414 | No |
| 16 | 4725 | NA | NDUFS5 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | 10048 | 0.010 | -0.2519 | No |
| 17 | 4719 | NA | NDUFS1 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 10341 | 0.006 | -0.2643 | No |
| 18 | 4706 | NA | NDUFAB1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 10497 | 0.004 | -0.2707 | No |
| 19 | 4536 | NA | ND2 Entrez, Source | MTND2 | 10741 | 0.000 | -0.2817 | No |
| 20 | 4709 | NA | NDUFB3 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa | 10894 | -0.002 | -0.2883 | No |
| 21 | 4539 | NA | ND4L Entrez, Source | NADH dehydrogenase, subunit 4L (complex I) | 11123 | -0.005 | -0.2978 | No |
| 22 | 4713 | NA | NDUFB7 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | 11247 | -0.007 | -0.3022 | No |
| 23 | 4702 | NA | NDUFA8 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa | 11508 | -0.011 | -0.3122 | No |
| 24 | 4701 | NA | NDUFA7 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | 11509 | -0.011 | -0.3104 | No |
| 25 | 4731 | NA | NDUFV3 Entrez, Source | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa | 11900 | -0.017 | -0.3252 | No |
| 26 | 4538 | NA | ND4 Entrez, Source | NADH dehydrogenase, subunit 4 (complex I) | 11947 | -0.018 | -0.3242 | No |
| 27 | 4707 | NA | NDUFB1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa | 11968 | -0.018 | -0.3220 | No |
| 28 | 4710 | NA | NDUFB4 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa | 11992 | -0.019 | -0.3198 | No |
| 29 | 126328 | NA | NDUFA11 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | 12874 | -0.035 | -0.3539 | No |
| 30 | 4714 | NA | NDUFB8 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 13246 | -0.043 | -0.3635 | No |
| 31 | 4712 | NA | NDUFB6 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa | 13637 | -0.051 | -0.3725 | No |
| 32 | 4694 | NA | NDUFA1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa | 14192 | -0.063 | -0.3869 | No |
| 33 | 4726 | NA | NDUFS6 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) | 14517 | -0.071 | -0.3895 | Yes |
| 34 | 4728 | NA | NDUFS8 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) | 14681 | -0.075 | -0.3841 | Yes |
| 35 | 4720 | NA | NDUFS2 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | 15105 | -0.086 | -0.3887 | Yes |
| 36 | 4696 | NA | NDUFA3 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | 15137 | -0.087 | -0.3753 | Yes |
| 37 | 56901 | NA | NDUFA4L2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | 15339 | -0.092 | -0.3687 | Yes |
| 38 | 374291 | NA | NDUFS7 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) | 15548 | -0.098 | -0.3614 | Yes |
| 39 | 4698 | NA | NDUFA5 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 | 15753 | -0.104 | -0.3529 | Yes |
| 40 | 29078 | NA | NDUFAF4 Entrez, Source | NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 | 16308 | -0.121 | -0.3575 | Yes |
| 41 | 4704 | NA | NDUFA9 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa | 16427 | -0.124 | -0.3415 | Yes |
| 42 | 2475 | NA | MTOR Entrez, Source | mechanistic target of rapamycin (serine/threonine kinase) | 16530 | -0.128 | -0.3242 | Yes |
| 43 | 55967 | NA | NDUFA12 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 | 16639 | -0.131 | -0.3066 | Yes |
| 44 | 4700 | NA | NDUFA6 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa | 16657 | -0.132 | -0.2848 | Yes |
| 45 | 4717 | NA | NDUFC1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa | 17061 | -0.146 | -0.2780 | Yes |
| 46 | 4708 | NA | NDUFB2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa | 17128 | -0.149 | -0.2555 | Yes |
| 47 | 4724 | NA | NDUFS4 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | 17282 | -0.155 | -0.2359 | Yes |
| 48 | 51103 | NA | NDUFAF1 Entrez, Source | NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 | 18468 | -0.216 | -0.2528 | Yes |
| 49 | 2908 | NA | NR3C1 Entrez, Source | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 21034 | -0.516 | -0.2812 | Yes |
| 50 | 5563 | NA | PRKAA2 Entrez, Source | protein kinase, AMP-activated, alpha 2 catalytic subunit | 21960 | -1.895 | 0.0018 | Yes |
